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h2INDICATIONS/h2
Premarin is a mixture of estrogen hormones used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Premarin is sometimes used as part of cancer treatment in women and men. Premarin should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.
h2INSTRUCTIONS/h2
strongUse Premarin as directed by your doctor./strong
ul
liemDo not use the medication in larger amounts, or use it for longer than recommended by your doctor./em/li
liemPremarin is taken on a daily basis. For certain conditions, Premarin is given in a cycle, such as 25 days on followed by 5 days. Follow the directions on your prescription label./em/li
liemPremarin may be taken by mouth with or without food./em/li
liemTake Premarin with a full glass of water./em/li
liemTry to take the medicine at the same time each day./em/li
liemHave regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin./em/li
liemIt is important to take Premarin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely./em/li
liemTo be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your thyroid function may also need to be tested. Do not miss any scheduled appointments./em/li
liemIf you need to have any type of surgery, tell the surgeon ahead of time that you are taking Premarin. You may need to stop using the medicine for a short time./em/li
liemThis medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using Premarin./em/li
liemIf you miss a dose of Premarin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once./em/li
/ul
strongAsk your health care provider any questions you may have about how to use Premarin./strong
h2STORAGE/h2
Store Premarin between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Keep Premarin out of the reach of children and away from pets.

Premarin (conjugated estrogens tablets) for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares’ urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17О±-dihydroequilin, 17О±- estradiol, and 17ОІ-dihydroequilin.

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Premarin tablets also contain the following inactive ingredients: calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, and titanium dioxide.
h3Do NOT use Premarin if:/h3
ul
liemyou are allergic to any ingredient in Premarin/em/li
liemyou are pregnant or suspect you may be pregnant/em/li
liemyou have a history of known or suspected breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent/em/li
liemyou have abnormal vaginal bleeding of unknown cause/em/li
liemyou have liver problems or liver disease, or the blood disease porphyria/em/li
liemyou have recently (within the last year) had a stroke or heart attack/em/li
liemyou have blood clots or circulation disorders./em/li
/ul
Contact your doctor or health care provider right away if any of these apply to you.

strongSome medical conditions may interact with Premarin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:/strong
ul
liemif you are planning to become pregnant, or are breast-feeding/em/li
liemif you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement/em/li
liemif you have allergies to medicines, foods, or other substances/em/li
liemif you have an abnormal mammogram/em/li
liemif you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood/em/li
liemif you use tobacco, you are going to have surgery, or you will be on bed rest/em/li
liemif you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer./em/li
/ul
strongSome medicines may interact with Premarin. Tell your health care provider if you are taking any other medicines, especially any of the following:/strong
ul
liemHydantoins (eg, phenytoin) or rifampin because they may decrease Premarin’s effectiveness./em/li
/ul
This may not be a complete list of all interactions that may occur. Ask your health care provider if Premarin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

strongImportant safety information:/strong
ul
liemPremarin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Premarin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it./em/li
liemSmoking while taking Premarin may increase your risk of blood clots (especially in women older than 35 years of age)./em/li
liemBefore using Premarin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear./em/li
liemYou should have periodic mammograms as determined by your doctor. Follow your doctor’s instructions for examining your own breasts, and report any lumps immediately./em/li
liemIf you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options./em/li
liemDiabetes patients – Premarin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine./em/li
liemPremarin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing./em/li
liemIf you wear contact lenses and you develop problems with them, contact your doctor./em/li
liemIf you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Premarin./em/li
liemPremarin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Premarin./em/li
liemLab tests, including a lipid profile, may be performed while you use Premarin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments./em/li
liemPremarin may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Premarin./em/li
liemPregnancy and breast-feeding: Do not use Premarin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Premarin is found in breast milk. If you are or will be breast-feeding while you use Premarin, check with your doctor. Discuss any possible risks to your baby./em/li
/ul
All medicines may cause side effects, but many people have no, or minor, side effects.

strongCheck with your doctor if any of these most common side effects persist or become bothersome:/strong

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

strongSeek medical attention right away if any of these severe side effects occur:/strong

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; confusion; dizziness; fainting; hoarseness; mental/mood changes; one-sided weakness; pain or tenderness in the upper abdomen; pain or tenderness in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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